1. What is coeliac disease? Relate your answer to the function of the villi and how they are adapted for their function.
First things first, what is coeliac disease?
- Coeliac disease (pronounced see-liac, spelt celiac disease in other countries) is an autoimmune disease.
- Gluten, which is found in wheat, barley and rye triggers an immune reaction in people with coeliac disease.
- This means that eating gluten damages the lining of the small intestine. Other parts of the body may be affected.
- diarrhoea, excessive wind, and/or constipation
- persistent or unexplained gastrointestinal symptoms, such as nausea and vomiting
- recurrent stomach pain, cramping or bloating
- any combination of iron, vitamin B12 or folic acid deficiency
- tiredness and/or headaches
- weight loss (but not in all cases)
- mouth ulcers
- hair loss (alopecia)
- skin rash (dermatitis herpetiformis (DH))
- tooth enamel problems
- osteoporosis
- depression
- infertility
- repeated miscarriages
- joint and/or bone pain
- neurological (nerve) problems such as ataxia (poor muscle co-ordination) and neuropathy (numbness and tingling in the hands and feet).
In babies, symptoms may develop after weaning onto cereals which contain gluten.
Other symptoms in young children include:
- muscle wasting in the arms and legs
- bloated tummy
- irritability
- failure to gain weight or lose weight after previously growing well
- Vili are folds in the walls of the gastrointestinal tract (intestines) which increasesurface area.
- Basically, as food and stuff you've ingested is pushed past, all these little folds (vili and microvili), they absorbs the nutrients you need in your body.
- And being folded lots of times means greater surface area and therefore its easier to get the nutrients!
- The small intestine lining is covered by millions of villi, finger-like projections, which act to increase the surface area of the intestine allowing increased absorption of nutrients.
- The villi are damaged by the inflammation in CD, which results in a decrease in the absorption of food.
- When gluten is removed from the diet inflammation is reduced and the intestine begins to heal.
- The time when a patient develops symptoms varies from patient to patient after their first contact with the gluten protein.
- In many cases is may be decades before symptoms and signs develop, often precipitated by a trigger.
- Barley
- Einkorn
- Kamut
- Rye
- Spelt
- Triticale
- Wheat
- No. There is no other treatment currently available.
- All patients with CD must remain on a strict gluten free diet.
- Medications are not normally required. Supplemental vitamins, calcium and magnesium may sometimes be recommended but patients are advised to check with their physician about these supplements.
- Rarely steroids or other drugs are used to suppress the immune system but only in the most severe of cases.
11. Where can I find more information on Celiac Disease?
http://www.celiac.org/
http://www.csaceliacs.org/
http://clinicaltrials.gov/ct/gui/action/FindCondition?ui=D002446&recruiting=true
http://www.naspghan.org